ICSI is a treatment primarily designed to overcome male fertility problems.
For a women's egg to be fertilized by the man's sperm. The sperm should attach to the outside layer of the egg. After the sperm is attached to the egg's outer layer, it shall push inside the egg to the cytoplasm, where fertilization occurs.
Sometimes the sperm cannot enter the egg's outer layer for many reasons. To help the sperm reach the egg's cytoplasm, we apply a procedure called intra-cytoplasmic sperm injection (ICSI). ICSI help increase the fertilization rate of the egg. In ICSI, a single sperm is injected directly into the egg's cytoplasm.
In the ICSI process, a tiny needle injects a single sperm into the center of the egg. The embryologist will choose the best sperm through different technologies, like IMSI, and inject it into the sperm. Through the technologies we offer, we can increase the rate of fertilization.
The fertilization rate is much higher using ICSI, and that's why ICSI (Intra-cytoplasmic Sperm Injection) procedure is carried out as standard as part of all our IVF treatments to ensure fertilization at no extra charge.
ICSI helps to overcome fertility problems; especially in such cases:
Male factor infertility.
Low egg quality.
In vitro matured eggs are being used.
Fertilization of frozen eggs.
The process of starting ICSI includes a list of steps:
First step: Evaluation
In this step, the doctor will need to look up the patient's medical history. If the patient has had previous IVF treatments, we would appreciate it if the patient could get a copy of the records to help the doctor evaluate the situation. Both partners will need to undergo some medical tests.
Second step: Hysterosalpingography (HSG) & Blood Assessment
Hysterosalpingography (HSG) is an X-ray procedure used to view the inside of the uterus and fallopian tubes. It often is used to see if the fallopian tubes are partly or wholly blocked. It also can show if the inside of the uterus is an average size and shape. The doctor will request an ultrasound scan for the patient, but we would prefer if the patient could do a Hysterosalpingography, especially if the patient had previous failed cycles.
The Female and male partners will be requested to make specific medical tests to assess their fertility. According to the blood assessments and scans from the patients, the doctor may ask for further investigation or prescribe some medications before starting the treatment.
Third Step: Medical Protocol
The patient will receive a personalized medical protocol. We will prescribe the patient stimulation medications to start using on day 2 or 3 of her period. The stimulation medications are hormonal injections to allow the follicles in the ovaries to grow. The patient will use the injections for an estimated period of 10 days. Through the ten days of stimulation medications, the patient might need an ultrasound scan to assess the follicle's development.
The medical protocol & medicines are prescribed to each patient according to each patient's situation.
Fourth Step: Egg retrieval & Fertilization
Once the follicles reach the needed size, the patient will take a trigger injection. The patient will be given a trigger injection 36 hours before egg retrieval. The patient will do a few medical tests (Estradiol & progesterone) before taking the trigger injection. These medical tests will determine if it's okay to make a fresh embryo transfer or if it's better to make a frozen embryo transfer on the next cycle.
Egg Retrieval Day
We will need the patient to come to the clinic fasting. The patient shall not eat or drink anything 6 hours before egg retrieval because anesthesia will be administered. The sperm sample will be taken on egg retrieval day to start the fertilization. (We recommend 3-5 days of abstinence before giving the sperm sample).
The fertilization of egg and sperm will be carried out by the embryologists using the latest techniques to help increase the fertilization rate. These techniques are Intra Cytoplasmic Sperm Injection (ICSI) Method & Intracytoplasmic Morphologically Selected Sperm Injection (IMSI).
Patients are updated regularly about their embryo fertilization.
Fifth Step: Embryo Transfer
On the day of embryo transfer, the patient shall come to the clinic with a full bladder. The full bladder will allow the doctor to see the endometrium lining clearly with the ultrasound guidance. The embryo transfer procedure is painless, and the patient will be awake.
After the embryo transfer, the patient coordinator will give you a kit stating everything you are not allowed to do and things to help you. You will also get a paper with all the medications you need to use and the period of usage.
Twelve days after embryo transfer, an HCG blood test can be done to test for pregnancy.
The needed amount to stay in Cyprus for IVF Treatment:
The first option; is 20 days: The patient can come for the entire treatment process and stay in Cyprus. The patient must come to Cyprus on the first or second day of the menstruation cycle. The patient will have all the medications and ultrasound scan monitors at the clinic.
The second option; is ten days: The patient will be able to start the treatment in their home country. And come to Cyprus on day 10 of the menstruation cycle. The patient will need to be in Cyprus before administering the trigger injection. The patient will have a few ultrasound scan monitors in their home country, and we will help the patient. As for the medications, we work with many online pharmacies, and we will help the patients to order the drugs or send them by post from Cyprus.
Please don't hesitate to contact us for further information about ICSI treatment in Cyprus.
You may find all the needed medical tests from the female and male partner in the Guide button.